abstract：OBJECTIVE:This study aims to investigate whether HOX transcript antisense RNA (HOTAIR) can participate in the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by regulating the Wnt/β-catenin pathway, thereby participating in the pathogenesis of osteoporosis. PATIENTS AND METHODS:We detected the...

journal_title：European review for medical and pharmacological sciences

authors： Shen JJ,Zhang CH,Chen ZW,Wang ZX,Yang DC,Zhang FL,Feng KH

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:Bladder cancer is considered as the fifth most common cancer in the whole world. This study aimed to investigate the anti-tumor effects of Nanoscale bubbles delivered yeast cytosine deaminase thymidine kinase/connexin 26 (YCD-TK/Cx26) on tumor cell proliferation and tumor growth. MATERIALS AND METHODS:Nanosc...

journal_title：European review for medical and pharmacological sciences

authors： Fu YR,Luo Y,Xie X,Lu W,Zhang R,Xiong B,Chen F

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:The X-linked inhibitor of apoptosis protein (XIAP) is associated with the development of various tumors. The abnormal miR-142 expression is associated with the onset of lung cancer. Bioinformatics analysis revealed a targeted relationship between miR-142 and XIAP. This report investigated whether miR-142 play...

journal_title：European review for medical and pharmacological sciences

authors： Wu XB,Li QH,Zhang N,Li M,Li K

更新日期：2019-09-01 00:00:00

abstract：:Capnocytophaga canimorsus is a Gram-negative rods frequently isolated as commensal in the saliva of pets that can be transmitted to humans. We report a case of septic shock caused by this pathogen. A 78-year-old man affected by diabetes and hypertension was admitted for fever in our Emergency Department. He reported f...

journal_title：European review for medical and pharmacological sciences

authors： Sabia L,Marchesini D,Pignataro G,Navarra SM,Saviano A,Giuliano G,De Luca G,Covino M,Franceschi F,Candelli M

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:Familial atrial fibrillation (FAF), a not uncommon arrhythmia of the atrium, is characterized by heritability, early onset and absence of other heart defects. The molecular and genetic basis is still not completely clear and genetic diagnosis cannot be achieved in about 90% of patients. In this study, we pres...

journal_title：European review for medical and pharmacological sciences

authors： Maltese PE,Aldanova E,Kriuchkova N,Averianov A,Manara E,Paolacci S,Bruson A,Miotto R,Sartori M,Guerri G,Zuntini M,Marceddu G,Tezzele S,Tadtaeva K,Chernova A,Aksyutina N,Nikulina S,Nodari S,Bertelli M

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to investigate the relation between CaMKII S-nitrosylation and its activation, as well as the underlying mechanism, after global cerebral ischemia-reperfusion. MATERIALS AND METHODS:The rat model of cerebral ischemia-reperfusion was established by four-vessel occlusion of 15 min and ...

journal_title：European review for medical and pharmacological sciences

authors： Yu LM,Zhang TY,Yin XH,Yang Q,Lu F,Yan JZ,Li C

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of micro ribonucleic acid (miR)-21 on rats with rheumatoid arthritis (RA) through the Wnt signaling pathway. MATERIALS AND METHODS:A total of 30 rats were divided into three groups: control group (healthy rats, n=10), model group (rat model of RA, n=10), and MiR group (rat model ...

journal_title：European review for medical and pharmacological sciences

authors： Liu XG,Zhang Y,Ju WF,Li CY,Mu YC

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To study the protective effect of glutamine on the intestinal tissues of septic rats by regulating the nuclear factor-κB (NF-κB) pathway. MATERIALS AND METHODS:A total of 30 rats were divided into the Sham group, Model group, and Glutamine group using a random number table. The changes in the intestinal tiss...

journal_title：European review for medical and pharmacological sciences

authors： Wu TY,Zhang HB

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:Recently, the vital role of circular RNAs is discovered in many diseases, including tumor progression. Non-small cell lung cancer (NSCLC) is one of the most ordinary malignant tumors. The purpose of our study is to detect the potential function of circ_0017247 in NSCLC to offer new biomarkers and targets. PA...

journal_title：European review for medical and pharmacological sciences

authors： Li CH,Wang YB,Chen KB

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To clarify the role of LINC00702 in the progression of ovarian cancer (OC) and the potential mechanism. PATIENTS AND METHODS:Expression level of LINC00702 in OC tissues and matched normal tissues was detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). LINC00702 level in OC cell lines was ...

journal_title：European review for medical and pharmacological sciences

authors： Wang L,Ye TY,Wu H,Chen SY,Weng JR,Xi XW

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to elucidate the expression pattern and potential function of LINC01116 in regulating the progression of osteosarcoma. PATIENTS AND METHODS:Expression levels of LINC01116 in osteosarcoma tissues (n=52) and adjacent normal tissues (n=52) were detected by quantitative Real-time polyme...

journal_title：European review for medical and pharmacological sciences

authors： Zhang ZF,Xu HH,Hu WH,Hu TY,Wang XB

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:Janus kinase (JAK)- signal transducer and transcriptional activator (STAT) pathway overactivation is closely related to tumorigenesis. Cytokine signal transduction inhibitor 3 (SOCS3) is a negative regulator of JAK-STAT. It is shown that miR-203 is significantly elevated in the pancreatic cancer tissues. The ...

journal_title：European review for medical and pharmacological sciences

authors： Lin XM,Chen H,Zhan XL

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:Metastatic melanoma, which is refractory to therapies, is one of the most aggressive types in skin cancers. microRNAs (miRNAs) have recently emerged as novel molecules which have therapeutic effects on melanoma. This study focused on the roles and mechanisms of miR-200a in melanoma progression. PATIENTS AND ...

journal_title：European review for medical and pharmacological sciences

authors： Chen WY,Xu YY,Zhang XY

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To observe the effect of micro ribonucleic acid (miR)-9 on the myocardial fibrosis (MF) in rats and explore its mechanism of action. MATERIALS AND METHODS:A total of 30 rats were selected to prepare the models of MF and randomly divided into Sham group, Model group and MiR-9 group. The rat heart weight (HW)/...

journal_title：European review for medical and pharmacological sciences

authors： Jin X,Yu LL,Yu CX

更新日期：2019-08-01 00:00:00

abstract：:Leukemia is a malignant disease of the blood system. Although the current research on the pathogenesis of leukemia is more and more in-depth and has an influential guiding significance for the ongoing clinical treatment of leukemia, its resistance and recurrence is still a challenging problem that needs to be solved. ...

journal_title：European review for medical and pharmacological sciences

authors： Zhang LP,Zhang MY,Liu WJ

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:Previous studies have demonstrated that long non-coding ribonucleic acid (lncRNA) FEZF1-AS1 acts as a cancer-promoting gene. However, no reports have investigated the role of FEZF1-AS1 in oral squamous cell carcinoma (OSCC) yet. Therefore, the aim of this study was to explore whether FEZF1-AS1 promoted the ex...

journal_title：European review for medical and pharmacological sciences

authors： Xu L,Hou TJ,Yang P

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:The abnormal expression of lncRNA small nucleolar RNA host gene 7 (SNHG7) has been found in various kinds of cancers but its expression and role in breast cancer are unknown. We conducted this study to identify the expression, the function, and to underline the mechanism of SNHG7 in breast cancer. PATIENTS A...

journal_title：European review for medical and pharmacological sciences

authors： Gao YT,Zhou YC

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To explore the anti-apoptotic effect of perindopril on myocardial cells in mice with acute myocardial infarction (AMI). MATERIALS AND METHODS:A total of 48 mice were randomly divided into 4 groups before intervention, namely sham operation group (Sham group, n=12), AMI group (n=12), 1.5 mg/kg perindopril tre...

journal_title：European review for medical and pharmacological sciences

authors： Wang XZ,Yu ZX,Nie B,Chen DM

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To observe whether edaravone has a therapeutic and protective effect on retinal injury in diabetic rats through the nuclear factor-κB (NF-κB) pathway. MATERIALS AND METHODS:The Sprague-Dawley rat model of diabetes was established and divided into diabetes model group (model group) and edaravone treatment gro...

journal_title：European review for medical and pharmacological sciences

authors： Wan YJ,Hu L,Wang XM

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:The aim of this qualitative review is to provide an update on the current understanding of the genetic determinants of lipedema and to develop a genetic test to differentiate lipedema from other diagnoses. MATERIALS AND METHODS:An electronic search was conducted in MEDLINE, PubMed, and Scopus for articles pu...

journal_title：European review for medical and pharmacological sciences

authors： Paolacci S,Precone V,Acquaviva F,Chiurazzi P,Fulcheri E,Pinelli M,Buffelli F,Michelini S,Herbst KL,Unfer V,Bertelli M,GeneOb Project.

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:GSK-3β negatively regulates Wnt/β-catenin signaling pathway. The abnormal miR-155 expression is associated with bladder cancer. Bioinformatics analysis revealed a complementary binding site between miR-155 and GSK-3β mRNA. This study investigated the role of miR-155 in the proliferation and apoptosis of bladd...

journal_title：European review for medical and pharmacological sciences

authors： Dong ZC,Zhang D,Zhang XX,Yao ZQ,Wu H,Chen CH,Tian JQ

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To investigate the association between bone morphogenetic protein 4 (BMP4) expression and clinical pathology, computed tomography (CT) characteristics and prognosis of patients with non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:A total of 76 NSCLC patients treated in our hospital from July 2012 to...

journal_title：European review for medical and pharmacological sciences

authors： Ju FJ,Meng FQ,Hu HL,Liu J

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To elucidate the function of long non-coding RNA (lncRNA) SNHG1 in acute myeloid leukemia (AML) and to explore its biological mechanism. PATIENTS AND METHODS:Expression levels of lncRNA SNHG1 and miR-488-5p in AML cell lines pAML and THP-1 were determined by quantitative Real Time-Polymerase Chain Reaction (...

journal_title：European review for medical and pharmacological sciences

authors： Bao XL,Zhang L,Song WP

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:We aimed at investigating the clinical efficacy of recombinant human basic fibroblast growth factor combined with compound polymyxin B ointment and the local application of insulin on wound healing of deep second-degree burn in diabetes mellitus. PATIENTS AND METHODS:80 diabetes mellitus patients complicated...

journal_title：European review for medical and pharmacological sciences

authors： Zhang JB,Li H,Zhang L,Wang JL

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:The previous research revealed that long noncoding RNAs (lncRNAs) play a vital role in the development of hepatocellular carcinoma (HCC). To further discuss the underlying mechanisms of lncRNA DCST1-AS1 in the pathogenesis of HCC. PATIENTS AND METHODS:We screened the abnormally expressed genes in HCC tissues...

journal_title：European review for medical and pharmacological sciences

authors： Li J,Zhai DS,Huang Q,Chen HL,Zhang Z,Tan QF

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:This study aimed to detect the expression of microRNA-378 in OSCC, and further studies its effects on clinicopathology and prognosis of OSCC patients. PATIENTS AND METHODS:Real-Time quantitative Polymerase Chain Reaction (RT-qPCR) was used to detect the expression levels of microRNA-378 in 96 pairs of OSCC t...

journal_title：European review for medical and pharmacological sciences

authors： Ding N,Luo M,Liao XL,Bao QY,Li RY,Wu B

更新日期：2019-07-01 00:00:00

abstract：:Madelung's disease is a rare condition characterized by symmetric growth of fatty tumors (lipomas) around the neck, shoulders, upper arms, and trunk. It often affects men with a history of alcohol abuse. Here we report a review of the literature about this disease together with the description of a patient affected by...

journal_title：European review for medical and pharmacological sciences

authors： Vassallo GA,Mirijello A,Tarli C,Rando MM,Antonelli M,Garcovich M,Zocco MA,Sestito L,Mosoni C,Dionisi T,D'Addio S,Tosoni A,Gasbarrini A,Addolorato G

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the influences of propofol on myocardial ischemia/reperfusion injury in rats through the Janus kinase/signal transducers and the activators of transcription (JAK/STAT) signaling pathway. MATERIALS AND METHODS:A total of 48 Sprague-Dawley (SD) rats were randomly divide...

journal_title：European review for medical and pharmacological sciences

authors： Chen X,Wang Y,Xiao ZY,Hou DN,Li DB,Zhang XP

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:To investigate the relationship between the interleukin-10 (IL-10) gene polymorphism and the pathogenesis of diabetic retinopathy (DR). PATIENTS AND METHODS:According to the fundus examination report, 420 patients with diabetes were divided into the non-DR group (n=200) and the DR group (n=220). The singl...

journal_title：European review for medical and pharmacological sciences

authors： Shi YL,Shi MY,Yin LZ,Shang JM,Zhuang JY

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Long stress-induced noncoding transcripts 5 (LSINCT5) has been reported to be upregulated in several human cancers and related to poor prognosis. However, its involvement in esophageal squamous cell carcinoma (ESCC) remains largely unknown. We aim to evaluate the expression and putative role of LSINCT5 on the...

journal_title：European review for medical and pharmacological sciences

authors： Jing L,Lin J,Zhao Y,Liu GJ,Liu YB,Feng L,Yang HY,Cui WX,Zhang XH

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To explore whether micro ribonucleic acid (miR)-7 affects the resistance of breast cancer cells to adriamycin (ADR) through regulating the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-hydroxy kinase (PI3K) signaling pathway. MATERIALS AND METHODS:MiR-7 expression was compared among MCF-10A,...

journal_title：European review for medical and pharmacological sciences

authors： Huang Q,Wu YY,Xing SJ,Yu ZW

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to explore the relationship between the mitogen-activated protein kinase (MAPK)/extracellular regulated protein kinase (ERK) pathway and neurocyte apoptosis after cerebral infarction in rats. MATERIALS AND METHODS:Neural stem cells were isolated from rats by establishing the cerebra...

journal_title：European review for medical and pharmacological sciences

authors： Wang QC,Lu L,Zhou HJ

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:The previous work has shown that Berberine and Hesperidin have beneficial effects on cardiovascular diseases. However, the underlying mechanisms remain unknown. This study aimed to investigate the effect of Berberine and Hesperidin on inflammatory cytokine secretion, proliferation, differentiation, and collag...

journal_title：European review for medical and pharmacological sciences

authors： Yu XH,Wang YF,Dai FY,Zhao JH,Li P

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Reduced expression of suppressors of cytokine signaling 3 (SOCS3) is associated with a variety of tumors. The elevated miR-155 expression is associated with the onset of pancreatic cancer. Bioinformatics analysis revealed a targeted relation between miR-155 and the 3'-UTR of SOCS3. This study investigated whe...

journal_title：European review for medical and pharmacological sciences

authors： Wang J,Guo J,Fan H

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Synovial inflammation plays an important role in the pathogenesis of osteoarthritis (OA), and β4GalT1 has been reported to be involved in the inflammatory process. The aim of our study was to investigate the role of β4GalT1 in the progression of inflammation and analyze the association between β4GalT1 and tum...

journal_title：European review for medical and pharmacological sciences

authors： Xu DW,Zhu XH,He MQ,Yuan Q,Dong QR

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Recently, the role of long noncoding RNAs (lncRNAs) in tumor progression has caught attention in numerous researchers. In our investigation, lncRNA PCAT-1 was studied to identify how it functioned in the progression of ovarian cancer. PATIENTS AND METHODS:LncRNA PCAT-1 expression was detected by quantitative...

journal_title：European review for medical and pharmacological sciences

authors： Liu HP,Lv D,Wang JY,Zhang Y,Chang JF,Liu ZT,Tang N

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:This study aims to detect the expression pattern of microRNA-375 in colorectal cancer (CRC), and to examine its specific mechanism in regulating the progression of CRC. PATIENTS AND METHODS:We detected microRNA-375 expression in 50 pairs of CRC and paracancerous tissues by quantitative real-time polymerase c...

journal_title：European review for medical and pharmacological sciences

authors： Wei LJ,Bai DM,Wang ZY,Liu BC

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Recent studies have revealed the vital role of long non-coding RNAs (lncRNAs) in tumor progression. This study aims to determine whether lncRNA HOXA-AS2 functions in the metastasis of non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:Quantitative Real Time-Polymerase Chain Reaction (QRT-PCR) was condu...

journal_title：European review for medical and pharmacological sciences

authors： Zheng FX,Wang XQ,Zheng WX,Zhao J

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to explore the regulatory mechanism of micro ribonucleic acid (miR)-223 in ulcerative colitis (UC) through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)-mammalian target of rapamycin (mTOR) signaling pathway. MATERIALS AND METHODS:A total of 36 Sprague-Dawley (SD) ...

journal_title：European review for medical and pharmacological sciences

authors： Jiang W,Han YP,Hu M,Bao XQ,Yan Y,Chen G

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Asthma is the most common chronic airway inflammatory disease. Sirtuin 1 (SIRT1) exerts a crucial effect on regulating chronic inflammatory responses. Therefore, this study aims to explore the effect of SIRT1 on the pathogenesis of asthma. MATERIALS AND METHODS:Serum level of SIRT1 in asthma patients and hea...

journal_title：European review for medical and pharmacological sciences

authors： Zhang YZ,Wu QJ,Yang X,Xing XX,Chen YY,Wang H

更新日期：2019-06-01 00:00:00